Akwesasne is a First Nations community of approximately 12,300 people (2016) distributed over an area of 11,720 acres and governed by the Mohawk Council of Akwesasne (MCA). The community comprises three districts: Kawehno:ke (Cornwall Island, Ontario), Kana:takon (St. Regis, Quebec) and Tsi Snaihne (Snye, Quebec). The objectives of this PIEVC assessment were 1) to evaluate the vulnerability to climate changes of the water and wastewater infrastructure of the MCA, and provide recommendations on possible adaptation measures to mitigate risks identified; and 2) Use the application of the PIEVC Protocol for Akwesasne water and wastewater infrastructure for knowledge transfer and to build capacity for Akwesasne and OFNTSC staff for future projects.